MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression

Limin Pan; Jianan Liu; Qianjun He; Jianlin Shi

doi:10.1002/adma.201402752

MSN-mediated sequential vascular-to-cell nuclear-targeted drug delivery for efficient tumor regression

Adv Mater. 2014 Oct 22;26(39):6742-8. doi: 10.1002/adma.201402752. Epub 2014 Aug 26.

Authors

Limin Pan¹, Jianan Liu, Qianjun He, Jianlin Shi

Affiliation

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai, 200050, China.

PMID: 25159109
DOI: 10.1002/adma.201402752

Abstract

Mesoporous silica nanoparticles functionalized with peptides are developed for sequential drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the TAT peptide for nuclear targeting. Using this delivery strategy, a tumor in a murine xenograft model is successfully regressed.

Keywords: mesoporous materials; nuclear targeting; silica nanoparticles; targeted drug delivery; tumor regression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / metabolism*
Antineoplastic Agents / pharmacology
Blood Vessels / metabolism*
Cell Nucleus / metabolism*
Doxorubicin / chemistry
Doxorubicin / metabolism
Doxorubicin / pharmacology
Drug Carriers / chemistry*
Drug Carriers / metabolism*
Gene Products, tat / chemistry
HeLa Cells
Humans
Mice
Nanoparticles / chemistry*
Oligopeptides / chemistry
Porosity
Silicon Dioxide / chemistry*
Xenograft Model Antitumor Assays

Substances

Antineoplastic Agents
Drug Carriers
Gene Products, tat
Oligopeptides
Silicon Dioxide
arginyl-glycyl-aspartic acid
Doxorubicin