Invasive mycosis due to species of Blastobotrys in immunocompromised patients with reduced susceptibility to antifungals

J Clin Microbiol. 2014 Nov;52(11):4094-9. doi: 10.1128/JCM.01977-14. Epub 2014 Aug 27.

Abstract

Cases of invasive mycosis due to Blastobotrys serpentis and B. proliferans identified by sequencing in a preterm patient and a rhabdomyosarcoma patient, respectively, are reported. Both species revealed elevated fluconazole and echinocandin MICs by the CLSI broth microdilution method. Additionally, B. serpentis exhibited high amphotericin B MICs, thus posing serious therapeutic challenges.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Child
  • Drug Resistance, Fungal*
  • Echinocandins / pharmacology
  • Female
  • Fluconazole / pharmacology
  • Humans
  • Immunocompromised Host*
  • Infant, Newborn
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mycoses / microbiology*
  • Saccharomycetales / classification
  • Saccharomycetales / drug effects*
  • Saccharomycetales / genetics
  • Saccharomycetales / isolation & purification*
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • Echinocandins
  • Amphotericin B
  • Fluconazole

Associated data

  • GENBANK/KM056336
  • GENBANK/KM056337
  • GENBANK/KM056338
  • GENBANK/KM056339
  • GENBANK/KM056340
  • GENBANK/KM056341