H1N1 triggered recurrent acute necrotizing encephalopathy in a family with a T653I mutation in the RANBP2 gene

Pediatr Infect Dis J. 2015 Mar;34(3):318-20. doi: 10.1097/INF.0000000000000533.

Abstract

A 28-month-old infant presented with fever, vomiting and encephalopathy. Magnetic resonance imaging findings and family history confirmed a diagnosis of recurrent familial acute necrotizing encephalopathy (ANE1). We believe that this is the first description implicating the H1N1 viral strain as a trigger and the second report of a T653I mutation in the RANBP2 gene described in relation to ANE1.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amino Acid Substitution*
  • Brain / pathology
  • DNA Mutational Analysis
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / complications*
  • Leukoencephalitis, Acute Hemorrhagic / diagnosis*
  • Leukoencephalitis, Acute Hemorrhagic / etiology*
  • Magnetic Resonance Imaging
  • Molecular Chaperones / genetics*
  • Mutation*
  • Nuclear Pore Complex Proteins / genetics*

Substances

  • Molecular Chaperones
  • Nuclear Pore Complex Proteins
  • ran-binding protein 2