An fMRI study of emotional face encoding in youth at risk for bipolar disorder

W-L Tseng; B L Bones; R R Kayser; A K Olsavsky; S J Fromm; D S Pine; E Leibenluft; M A Brotman

doi:10.1016/j.eurpsy.2014.05.004

An fMRI study of emotional face encoding in youth at risk for bipolar disorder

Eur Psychiatry. 2015 Jan;30(1):94-8. doi: 10.1016/j.eurpsy.2014.05.004. Epub 2014 Aug 27.

Authors

W-L Tseng¹, B L Bones², R R Kayser², A K Olsavsky³, S J Fromm⁴, D S Pine⁴, E Leibenluft⁴, M A Brotman⁴

Affiliations

¹ Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Electronic address: [email protected].
² Georgetown University School of Medicine, Washington, DC, USA.
³ UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
⁴ Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

Abstract

Face memory deficits may be a bipolar disorder (BD) endophenotype. BD (n=27) and unaffected youth at risk (n=13) exhibited middle frontal gyrus hypoactivation during successful vs. unsuccessful encoding. Parahippocampal gyrus dysfunction was found in BD and at-risk youth (vs. low-risk, n=37). Middle occipital gyrus hypoactivation was only present in BD.

Keywords: At risk; Endophenotype; Face memory; Pediatric bipolar disorder; fMRI.

Publication types

Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Bipolar Disorder / physiopathology*
Bipolar Disorder / psychology*
Brain / physiopathology*
Emotions*
Endophenotypes
Facial Expression*
Female
Frontal Lobe / physiopathology
Humans
Magnetic Resonance Imaging*
Male
Memory
Occipital Lobe / physiopathology
Parahippocampal Gyrus / physiopathology
Risk

Grants and funding

ZIA MH002969/ImNIH/Intramural NIH HHS/United States