The authors report the first case of parrot breeder's lung in China and the study of its immunology, respiratory physiology, as well as pathology. The main characteristics of this disease are progressive dyspnea after contacting parrots, patchy or reticular shadows in the lower lung fields on chest X-ray, the presence of alveolitis, accompanied by pulmonary interstitial fibrosis as demonstrated in lung biopsy, restrictive or mixed ventilation disorders with reduction of diffusing capacity and lung compliance. The results of specific ring precipitation test and counter immunoelectrophoresis were helpful in diagnosis. The importance of early diagnosis and treatment is also discussed.