Drug interactions between voriconazole, darunavir/ritonavir and tenofovir/emtricitabine in an HIV-infected patient treated for Aspergillus candidus lung abscess

Int J STD AIDS. 2015 Aug;26(9):672-5. doi: 10.1177/0956462414549035. Epub 2014 Sep 1.

Abstract

We report an unusual case of pulmonary aspergillosis in a patient with AIDS and we demonstrated the drug-drug interactions between voriconazole, darunavir/ritonavir and tenofovir/emtricitabine. The combination darunavir-ritonavir-voriconazole should be avoided.

Keywords: AIDS; Aspergillus candidus; HIV; antiretroviral therapy; aspergillosis; drug-drug interactions; opportunistic infection; treatment; voriconazole.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy
  • Adult
  • Anti-HIV Agents / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy*
  • Aspergillus
  • Darunavir / therapeutic use
  • Drug Interactions*
  • Emtricitabine / therapeutic use
  • HIV Infections / drug therapy*
  • HIV Protease Inhibitors
  • Humans
  • Lung Abscess / diagnosis
  • Lung Abscess / drug therapy*
  • Male
  • Ritonavir / therapeutic use
  • Tenofovir / therapeutic use
  • Treatment Outcome
  • Voriconazole / therapeutic use*

Substances

  • Anti-HIV Agents
  • Antifungal Agents
  • HIV Protease Inhibitors
  • Tenofovir
  • Emtricitabine
  • Voriconazole
  • Ritonavir
  • Darunavir