An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

Meihua Yu; Yuting Niu; Yannan Yang; Sandy Budi Hartono; Jie Yang; Xiaodan Huang; Peter Thorn; Chengzhong Yu

doi:10.1021/am503060n

An approach to prepare polyethylenimine functionalized silica-based spheres with small size for siRNA delivery

ACS Appl Mater Interfaces. 2014 Sep 24;6(18):15626-31. doi: 10.1021/am503060n. Epub 2014 Sep 8.

Authors

Meihua Yu¹, Yuting Niu, Yannan Yang, Sandy Budi Hartono, Jie Yang, Xiaodan Huang, Peter Thorn, Chengzhong Yu

Affiliation

¹ Australian Institute for Bioengineering and Nanotechnology and ‡School of Biomedical Sciences, The University of Queensland , Brisbane, QLD 4072, Australia.

PMID: 25184370
DOI: 10.1021/am503060n

Abstract

A novel approach has been developed to prepare polyethylenimine functionalized hybrid silica spheres with a diameter of ∼10 nm, which show excellent delivery efficiency of siRNA into osteosarcoma cancer cells and human colon cancer cells with a significant cell inhibition comparable to commercial agents.

Keywords: gene delivery; polyethylenimine; siRNA; silica nanoparticles; surface modification.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacokinetics
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Drug Carriers / chemistry*
Gene Transfer Techniques*
Humans
Nanospheres / chemistry*
Particle Size
Polyethyleneimine / chemistry*
RNA, Small Interfering / chemistry
RNA, Small Interfering / pharmacokinetics*
RNA, Small Interfering / pharmacology
Silicon Dioxide / chemistry*
Surface Properties

Substances

Antineoplastic Agents
Drug Carriers
RNA, Small Interfering
Silicon Dioxide
Polyethyleneimine