Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes

In Vivo. 2014 Sep-Oct;28(5):919-23.

Abstract

Aim: There are two different types of diabetes mellitus, type 1 and type 2, with still unclear molecular mechanisms. In the present study, we aimed to investigate the role of small ubiquitin-like modifier 4 (SUMO4) M55V and nuclear factor kappa B1 (NFKB1)-94del/ins in type-2 diabetes mellitus.

Materials and methods: We analyzed SUMO4 M55V and NFKB1-94del/ins variants in 104 patients with type-2 diabetes and 124 healthy controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques.

Results: The number of SUMO4 M55V MM genotype and M allele carriers was significantly higher in patients compared to the control group; however, no efficiency results were found related to NFKB1-94del/ins polymorphism.

Conclusion: It was found that SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility. This preliminary study showed that the distribution of SUMO4 M55V and type-2 diabetes mellitus in Turkish patients may form the basis of future research.

Keywords: NFKB1; SUMO4; polymorphism; type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • INDEL Mutation*
  • Male
  • Middle Aged
  • NF-kappa B p50 Subunit / genetics
  • Polymorphism, Single Nucleotide
  • Risk Factors
  • Small Ubiquitin-Related Modifier Proteins / genetics*
  • Turkey

Substances

  • NF-kappa B p50 Subunit
  • NFKB1 protein, human
  • SUMO4 protein, human
  • Small Ubiquitin-Related Modifier Proteins