Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography

Marcel N Menke; Jens H Kowal; Pascal Dufour; Ute E Wolf-Schnurrbusch; Lala Ceklic; Carsten Framme; Sebastian Wolf

doi:10.1167/iovs.14-14412

Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography

Invest Ophthalmol Vis Sci. 2014 Sep 4;55(10):6575-9. doi: 10.1167/iovs.14-14412.

Authors

Marcel N Menke¹, Jens H Kowal², Pascal Dufour³, Ute E Wolf-Schnurrbusch⁴, Lala Ceklic⁴, Carsten Framme⁵, Sebastian Wolf⁴

Affiliations

¹ Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland Department of Ophthalmology, Cantonal Hospital Aarau, Aarau, Switzerland.
² Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland ARTORG Center of Biomedical Engineering Research, University of Bern, Bern, Switzerland.
³ ARTORG Center of Biomedical Engineering Research, University of Bern, Bern, Switzerland.
⁴ Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland.
⁵ Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland University Eye Hospital, Hannover Medical School, Hannover, Germany.

PMID: 25190655
DOI: 10.1167/iovs.14-14412

Abstract

Purpose: Optical coherence tomography (OCT) was used to analyze the thickness of various retinal layers of patients following successful macula-off retinal detachment (RD) repair.

Methods: Optical coherence tomography scans of patients after successful macula-off RD repair were reanalyzed with a subsegmentation algorithm to measure various retinal layers. Regression analysis was performed to correlate time after surgery with changes in layer thickness. In addition, patients were divided in two groups. Group 1 had a follow-up period after surgery of up to 7 weeks (range, 21-49 days). In group 2, the follow-up period was >8 weeks (range, 60-438 days). Findings were compared to a group of age-matched healthy controls.

Results: Correlation analysis showed a significant positive correlation between inner nuclear-outer plexiform layer (INL-OPL) thickness and time after surgery (P=0.0212; r2=0.1551). Similar results were found for the ellipsoid zone-retinal pigment epithelium complex (EZ-RPE) thickness (P=0.005; r2=0.2215). Ganglion cell-inner plexiform layer thickness (GCL-IPL) was negatively correlated with time after surgery (P=0.0064; r2=0.2101). For group comparison, the retinal nerve fiber layer in both groups was thicker compared to controls. The GCL-IPL showed significant thinning in group 2. The outer nuclear layer was significantly thinner in groups 1 and 2 compared to controls. The EZ-RPE complex was significantly thinner in groups 1 and 2 compared to controls. In addition, values in group 1 were significantly thinner than in group 2.

Conclusions: Optical coherence tomography retinal layer thickness measurements after successful macular-off RD repair revealed time-dependent thickness changes. Inner nuclear-outer plexiform layer thickness and EZ-RPE thickness was positively correlated with time after surgery. Ganglion cell-inner plexiform layer thickness was negatively correlated with time after surgery.

Keywords: OCT; image analysis; retinal detachment; subsegmentation.

Publication types

Comparative Study

MeSH terms

Female
Follow-Up Studies
Humans
Macula Lutea / pathology
Macula Lutea / surgery
Male
Middle Aged
Retinal Detachment / diagnosis*
Retinal Detachment / surgery
Retinal Ganglion Cells / pathology*
Retrospective Studies
Surgery, Computer-Assisted / methods*
Time Factors
Tomography, Optical Coherence / methods*
Treatment Outcome
Vitrectomy / methods*