Proline-glycine-proline as a potential biomarker in chronic obstructive pulmonary disease and cystic fibrosis

Arne Lucas Ten Hoeve; Mojtaba Abdul Roda; Frank Redegeld; Gert Folkerts; James Edwin Blalock; Amit Gaggar

Proline-glycine-proline as a potential biomarker in chronic obstructive pulmonary disease and cystic fibrosis

Tanaffos. 2012;11(2):12-5.

Authors

Arne Lucas Ten Hoeve¹, Mojtaba Abdul Roda¹, Frank Redegeld¹, Gert Folkerts¹, James Edwin Blalock², Amit Gaggar²

Affiliations

¹ Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.
² Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

PMID: 25191408
PMCID: PMC4153190

Abstract

The present review discusses the role of tri-peptide Proline -Glycine -Proline (PGP) as a potential player, biomarker and therapeutic target in this process.

Keywords: Chemotactic factors; Chronic obstructive pulmonary disease; Cystic fibrosis; Extracellular matrix; Interleukin-8 A and B; Neutrophil activation praline; Serine ednopeptidases.

Publication types

Review