Severe infective endocarditis with systemic embolism due to community associated methicillin-resistant Staphylococcus aureus ST630

Beiwen Zheng; Saiping Jiang; Zemin Xu; Yonghong Xiao; Lanjuan Li

doi:10.1016/j.bjid.2014.07.006

Severe infective endocarditis with systemic embolism due to community associated methicillin-resistant Staphylococcus aureus ST630

Braz J Infect Dis. 2015 Jan-Feb;19(1):85-9. doi: 10.1016/j.bjid.2014.07.006. Epub 2014 Sep 1.

Authors

Beiwen Zheng¹, Saiping Jiang², Zemin Xu³, Yonghong Xiao⁴, Lanjuan Li¹

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
² Department of Pharmacy, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ Ningbo Institute of Microcirculation and Henbane, Ningbo, China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China. Electronic address: [email protected].

Abstract

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) are increasingly causing infective endocarditis over the past decade. Here we report a healthy man who developed a severe acute infective endocarditis with systemic embolism caused by CA-MRSA. The strain was recovered from repeated blood cultures and was characterized using molecular detection and genotyping. The S. aureus isolate was typed as ST630 SCCmecV with spa-type t4549, agrI/IV and was PVL-negative. This is the only case report, to our knowledge, of CA-MRSA infective endocarditis in China. This case highlights the emergence and geographical spread of life-threatening CA-MRSA infection within China.

Keywords: Community-acquired MRSA; Infective endocarditis; ST 630; Surgical therapy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Community-Acquired Infections
Embolism, Paradoxical / etiology*
Endocarditis, Bacterial / complications
Endocarditis, Bacterial / microbiology*
Humans
Male
Methicillin-Resistant Staphylococcus aureus*
Severity of Illness Index
Staphylococcal Infections / complications
Staphylococcal Infections / microbiology*