Abstract
Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 µM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Biphenyl Compounds / chemistry
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Biphenyl Compounds / isolation & purification
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Caspase 3 / biosynthesis
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival
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Down-Regulation / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology
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Magnolia / chemistry*
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Molecular Conformation
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Plant Extracts / chemistry
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis
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Seeds / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Biphenyl Compounds
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Lignans
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Plant Extracts
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Proto-Oncogene Proteins c-bcl-2
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bishonokiol A
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magnolol
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honokiol
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Caspase 3