Flipping a phosphate switch on kinesin-II to turn IFT around

Branch Craige; George B Witman

doi:10.1016/j.devcel.2014.08.019

Flipping a phosphate switch on kinesin-II to turn IFT around

Dev Cell. 2014 Sep 8;30(5):492-3. doi: 10.1016/j.devcel.2014.08.019.

Authors

Branch Craige¹, George B Witman²

Affiliations

¹ Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
² Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: [email protected].

Abstract

Cilia and flagella are assembled and maintained by the motor-driven, bidirectional traffic of large protein complexes in a process termed intraflagellar transport (IFT). In this issue of Developmental Cell, Liang et al. (2014) report that IFT is regulated in part by the phosphorylation status of the kinesin-II subunit FLA8/KIF3B.

Publication types

Comment

MeSH terms

Animals
Calcium-Binding Proteins / metabolism*
Chlamydomonas reinhardtii / metabolism*
Flagella / physiology*
Gene Expression Regulation, Plant*
Kinesins / metabolism*

Substances

Calcium-Binding Proteins
kinesin-II
Kinesins

Abstract

Publication types

MeSH terms

Substances

Grants and funding