Intra-fraction uncertainties of MRI guided brachytherapy in patients with cervical cancer

Christel N Nomden; Astrid A C de Leeuw; Judith M Roesink; Robbert J H A Tersteeg; Henrike Westerveld; Ina M Jürgenliemk-Schulz

doi:10.1016/j.radonc.2014.08.010

Intra-fraction uncertainties of MRI guided brachytherapy in patients with cervical cancer

Radiother Oncol. 2014 Aug;112(2):217-20. doi: 10.1016/j.radonc.2014.08.010. Epub 2014 Sep 10.

Authors

Christel N Nomden¹, Astrid A C de Leeuw², Judith M Roesink², Robbert J H A Tersteeg², Henrike Westerveld³, Ina M Jürgenliemk-Schulz²

Affiliations

¹ University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands. Electronic address: [email protected].
² University Medical Centre Utrecht, Department of Radiation Oncology, The Netherlands.
³ Academic Medical Centre, Department of Radiotherapy, Amsterdam, The Netherlands.

PMID: 25216574
DOI: 10.1016/j.radonc.2014.08.010

Abstract

Dosimetric intra-fraction uncertainties in MRI-guided brachytherapy were analysed for HR-CTV and OARs. While dose differences were generally small, individual outliers occurred. In contrast to HDR, patients treated with PDR show increased mean rectal dose over time. Re-imaging prior to dose delivery helps to detect unfavorable anatomical changes, and allows for intervention.

Keywords: Cervix; Contouring; High dose rate; IGABT; Organ movement; Rectum morbidity.

MeSH terms

Antineoplastic Agents / administration & dosage
Brachytherapy / methods*
Chemoradiotherapy
Cisplatin / administration & dosage
Female
Humans
Magnetic Resonance Imaging, Interventional / methods*
Neoplasm Staging
Radiation-Sensitizing Agents / administration & dosage
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods*
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / radiotherapy*

Substances

Antineoplastic Agents
Radiation-Sensitizing Agents
Cisplatin