Elevated aspartate aminotransferase-to-platelet ratio index in perinatally HIV-infected children in the United States

Pediatr Infect Dis J. 2014 Aug;33(8):855-7. doi: 10.1097/INF.0000000000000348.

Abstract

Elevated aspartate aminotransferase-to-platelet ratio index may signal liver fibrosis. Among 397 US children with perinatal HIV infection, at baseline was >1.5 in 0.8% [95% confidence interval (CI), 0.2-2.2%) and >0.5 in 6.5% (95% CI, 4.3-9.4%); incidence on study was 0.5 (95% CI, 0.2-1.2) and 6.4 (95% CI, 4.8-8.3) per 100 person-years, respectively. Long-term liver outcomes after perinatal HIV infection warrant further study.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Aspartate Aminotransferases / blood*
  • Blood Platelets / pathology*
  • Child
  • Female
  • HIV Infections / blood*
  • HIV Infections / enzymology*
  • HIV Infections / epidemiology
  • HIV Infections / transmission
  • Humans
  • Infectious Disease Transmission, Vertical
  • Liver Cirrhosis / blood
  • Liver Cirrhosis / enzymology
  • Liver Cirrhosis / epidemiology
  • Liver Cirrhosis / virology
  • Male
  • Platelet Count
  • Prospective Studies
  • United States / epidemiology

Substances

  • Aspartate Aminotransferases