Quantification of the chemical composition variations of tumors in photothermal therapy by photoacoustic spectroscopy: an in vitro study

Yubin Liu; Zhifang Li; Hui Li; Zhen Yuan

doi:10.3233/BME-141165

Quantification of the chemical composition variations of tumors in photothermal therapy by photoacoustic spectroscopy: an in vitro study

Biomed Mater Eng. 2014;24(6):3411-8. doi: 10.3233/BME-141165.

Authors

Yubin Liu¹, Zhifang Li², Hui Li², Zhen Yuan³

Affiliations

¹ Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China.
² College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, China.
³ Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR, China.

PMID: 25227052
DOI: 10.3233/BME-141165

Abstract

In this study, the change of tumors' chemical composition in the temperature range of 20 ~70 °C is quantified for photothermal tumor therapy by photoacoustic spectroscopy (PAS) with the wavelengths of 700~1000 nm. Based on the measured photoacoustic signals, two absorption peaks at the wavelengths of 750 nm and 950 nm are identified. It is also observed that high temperature (>55 °C) is able to induce the physical and chemical degeneration of tumors. According to the in vitro tests, a new chemical species, met-hemoglobin, which is absent in normal blood, is generated at high temperature with enhanced near-infrared absorption.

Keywords: PAS; hemoglobin; photoacoustic signals; photothermal therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chickens
Hyperthermia, Induced / methods*
Methemoglobin / analysis*
Neoplasms, Experimental / chemistry*
Neoplasms, Experimental / therapy*
Photoacoustic Techniques / methods*
Phototherapy / methods*
Treatment Outcome

Substances

Methemoglobin