Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection

Int J Urol. 2015 Feb;22(2):222-5. doi: 10.1111/iju.12633. Epub 2014 Sep 18.

Abstract

Basaloid squamous cell carcinoma is a biologically aggressive neoplasm mainly found in the head and neck region. Recently, four cases of basaloid squamous cell carcinoma of the bladder have been reported, and three of them occurred in patients with neurogenic bladder, repeated catheterizations and human papillomavirus infection of the urinary tract. To the best of our knowledge, none of the patients affected by basaloid squamous cell carcinoma of the bladder described in the literature had documented genital involvement by human papillomavirus. Herein, we describe the case of a woman with neurogenic bladder affected by basaloid squamous cell carcinoma of the bladder and by a concomitant genital tract human papillomavirus infection.

Keywords: basaloid squamous cell carcinoma; bladder; epithelial-mesenchymal transition; human papillomavirus; p16.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Squamous Cell / diagnosis*
  • Carcinoma, Squamous Cell / therapy
  • Carcinoma, Squamous Cell / virology
  • Combined Modality Therapy
  • DNA, Viral / analysis
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Papillomaviridae / genetics*
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / diagnosis*
  • Papillomavirus Infections / therapy
  • Papillomavirus Infections / virology
  • Reproductive Tract Infections / diagnosis*
  • Reproductive Tract Infections / therapy
  • Reproductive Tract Infections / virology
  • Urinary Bladder / pathology
  • Urinary Bladder / virology*
  • Urinary Bladder Neoplasms / diagnosis*
  • Urinary Bladder Neoplasms / therapy
  • Urinary Bladder Neoplasms / virology

Substances

  • DNA, Viral