In vitro activity of trospectomycin (U-63366F), a novel spectinomycin analog, against gram-positive isolates from cancer patients

Eur J Clin Microbiol Infect Dis. 1989 Mar;8(3):254-60. doi: 10.1007/BF01965272.

Abstract

The in vitro activity of trospectomycin was compared to that of amikacin, cephalothin and vancomycin against gram-positive organisms, mostly isolated from cancer patients. Trospectomycin was considerably more active than amikacin against most isolates tested, particularly species of Staphylococcus and Streptococcus. Overall, vancomycin was the most active agent tested.

Publication types

  • Comparative Study

MeSH terms

  • Amikacin / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Cephalothin / pharmacology
  • Gram-Positive Bacteria / drug effects*
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Neoplasms / microbiology*
  • Spectinomycin / analogs & derivatives*
  • Spectinomycin / pharmacology
  • Staphylococcus / drug effects
  • Streptococcus / drug effects
  • Vancomycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • trospectomycin
  • Vancomycin
  • Amikacin
  • Spectinomycin
  • Cephalothin