Gut microbiota: a natural adjuvant for vaccination

Oliver Pabst; Mathias Hornef

doi:10.1016/j.immuni.2014.09.002

Gut microbiota: a natural adjuvant for vaccination

Immunity. 2014 Sep 18;41(3):349-351. doi: 10.1016/j.immuni.2014.09.002.

Authors

Oliver Pabst¹, Mathias Hornef²

Affiliations

¹ Institute of Molecular Medicine, RWTH University, 52074 Aachen, Germany. Electronic address: [email protected].
² Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, 30625 Hannover; Institute of Medical Microbiology, RWTH University, 52074 Aachen, Germany.

PMID: 25238091
DOI: 10.1016/j.immuni.2014.09.002

Abstract

In this issue of Immunity, Oh et al. (2014) reveal an unappreciated facet of how the microbiota influences immune responses. Immunity to nonadjuvanted vaccines depends on Toll-like-receptor-5-mediated sensing of the microbiota.

Publication types

Comment

MeSH terms

Animals
Antibody Formation / immunology*
Humans
Influenza Vaccines / immunology*
Intestines / microbiology*
Microbiota / immunology*
Toll-Like Receptor 5 / immunology*

Substances

Influenza Vaccines
Toll-Like Receptor 5