Rare presentation of secondary cutaneous involvement by splenic marginal zone lymphoma: report of a case and review of the literature

Am J Dermatopathol. 2015 Jan;37(1):e1-4. doi: 10.1097/DAD.0000000000000055.

Abstract

Cutaneous lymphomas encompass a broad spectrum of malignancies, including both primary and secondary cutaneous lymphomas. Determining the exact subtype of cutaneous lymphoma offers prognostic importance and directs therapeutic decisions. We describe the case of a 67-year-old woman with cutaneous involvement of splenic marginal zone lymphoma successfully treated with rituximab and bendamustine. We discuss the diagnostic work-up, including the histopathologic findings and treatment of this disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Murine-Derived / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bendamustine Hydrochloride
  • Biomarkers, Tumor / analysis
  • Biopsy
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphoma, B-Cell, Marginal Zone / chemistry
  • Lymphoma, B-Cell, Marginal Zone / drug therapy
  • Lymphoma, B-Cell, Marginal Zone / pathology*
  • Nitrogen Mustard Compounds / administration & dosage
  • Predictive Value of Tests
  • Remission Induction
  • Rituximab
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / drug therapy
  • Skin Neoplasms / secondary*
  • Splenic Neoplasms / chemistry
  • Splenic Neoplasms / drug therapy
  • Splenic Neoplasms / pathology*
  • Time Factors
  • Treatment Outcome

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Biomarkers, Tumor
  • Nitrogen Mustard Compounds
  • Rituximab
  • Bendamustine Hydrochloride