Frequent use of opioids in patients with dementia and nursing home residents: A study of the entire elderly population of Denmark

Alzheimers Dement. 2015 Jun;11(6):691-9. doi: 10.1016/j.jalz.2014.06.013. Epub 2014 Sep 16.

Abstract

Background: Pain is believed to be undertreated in patients with dementia; however, no larger studies have been conducted. The aim was to investigate prevalent use of opioids in elderly with and without dementia in the entire elderly population of Denmark.

Method: A register-based cross-sectional study in the entire elderly (≥65 years) population in 2010 was conducted. Opioid use among elderly with dementia (N = 35,455) was compared with elderly without (N = 870,645), taking age, sex, comorbidity, and living status into account.

Results: Nursing home residents (NHRs) used opioids most frequently (41%), followed by home-living patients with dementia (27.5%) and home-living patients without dementia (16.9%). Buprenorphine and fentanyl (primarily patches) were commonly used among NHRs (18.7%) and home-living patients with dementia (10.7%) but less often by home-living patients without dementia (2.4%).

Conclusions: Opioid use in the elderly Danish population was frequent but particularly in patients with dementia and NHR, which may challenge patient safety and needs further investigation.

Keywords: Buprenorphine; Dementia; Elderly; Fentanyl; Opioids; Pain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Analgesics, Opioid / therapeutic use*
  • Buprenorphine / therapeutic use
  • Comorbidity
  • Cross-Sectional Studies
  • Dementia / epidemiology*
  • Denmark
  • Female
  • Fentanyl / therapeutic use
  • Humans
  • Male
  • Medical Staff, Hospital
  • Nursing Homes / statistics & numerical data*
  • Pain / drug therapy*
  • Pain / epidemiology
  • Registries
  • Sex Factors

Substances

  • Analgesics, Opioid
  • Buprenorphine
  • Fentanyl