Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures

Affiliations

• ¹ 1] National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA [2] Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, California 94305, USA.
• ² National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA.
• ³ Interdisciplinary Centre for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, 04107 Leipzig, Germany.
• ⁴ Institute of Bioinformatics, Johannes Kepler University, Altenberger Str. 69, 4040 Linz, Austria.
• ⁵ Computational Genomics Program, Principe Felipe Research Center, Avd Eduardo Primo Yúfera 3, 46012 Valencia, Spain.
• ⁶ 1] Computational Genomics Program, Principe Felipe Research Center, Avd Eduardo Primo Yúfera 3, 46012 Valencia, Spain [2] CIBER de Enfermedades Raras (CIBERER) and Functional Genomics Node, INB., Valencia, Spain.
• ⁷ ecSeq Bioinformatics, Brandvorwerkstrasse 43, 04275 Leipzig, Germany.
• ⁸ National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.
• ⁹ Genomics Core Facility, Feinberg School of Medicine, Northwestern University, Tarry building 2-757, 300 E. Superior St. Chicago, Illinois 60611, USA.
• ¹⁰ 1] Chair of Bioinformatics, Boku University Vienna, Muthgasse 18, Vienna 1190, Austria [2] University of Warwick, Coventry CV4 7AL, UK.
• ¹¹ Chair of Bioinformatics, Boku University Vienna, Muthgasse 18, Vienna 1190, Austria.
• ¹² Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medical College, 1305 York Avenue, Room Y13-04, Box 140, New York, New York 10021, USA.
• ¹³ 1] Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.
• ¹⁴ Nationwide Children's Hospital, Columbus, Ohio 43205, USA.
• ¹⁵ 1] CIBER de Enfermedades Raras (CIBERER) and Functional Genomics Node, INB., Valencia, Spain [2] Medical Genome Project, Genomics and Bioinformatics Platform of Andalusia, c/ Albert Einstein s/n, 41092 Sevilla, Spain.
• ¹⁶ Thermo Fisher Scientific, Research &Development, 2170 Woodward Street, Austin, Texas 78744, USA.
• ¹⁷ State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Schools of Life Sciences and Pharmacy, Fudan University, Shanghai 201203, China.
• ¹⁸ 1] Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria 3010, Australia.
• ¹⁹ 1] Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia.
• ²⁰ Division of Microbiology and Molecular Genetics, Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA.
• ²¹ Research Informatics, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
• ²² Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, 1000 N Oak Avenue, Marshfield, Wisconsin 54449, USA.