Acute-onset postoperative endophthalmitis caused by multidrug-resistant Klebsiella pneumoniae

Shekhar Sanghi; Avinash Pathengay; Animesh Jindal; Vishal Raval; Sameera Nayak; Savitri Sharma; Abhishek Bawdekar; Harry W Flynn Jr

doi:10.2147/OPTH.S67894

Acute-onset postoperative endophthalmitis caused by multidrug-resistant Klebsiella pneumoniae

Clin Ophthalmol. 2014 Sep 16:8:1783-5. doi: 10.2147/OPTH.S67894. eCollection 2014.

Authors

Shekhar Sanghi¹, Avinash Pathengay¹, Animesh Jindal¹, Vishal Raval², Sameera Nayak², Savitri Sharma³, Abhishek Bawdekar¹, Harry W Flynn Jr⁴

Affiliations

¹ Department of Ophthalmology, L V Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, Andhra Pradesh, India.
² Department of Ophthalmology, L V Prasad Eye Institute, KVC Campus, Vijayawada, Andhra Pradesh, India.
³ Department of Microbiology, Jhaveri Microbiology Centre, L V Prasad Eye Institute, KAR Campus, Hyderabad, Andhra Pradesh, India.
⁴ Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.

Abstract

The purpose of this paper is to report outcomes of intravitreal imipenem in the treatment of multidrug-resistant Klebsiella-related postoperative endophthalmitis. This observational case series consists of three eyes from three patients seen between 2013 and 2014. Multidrug-resistant Klebsiella pneumoniae is characterized by a rapid, fulminant course and severe intraocular inflammation. Intravitreal imipenem may be used to treat such infection.

Keywords: Klebsiella pneumoniae; imipenem; multidrug resistance; postoperative endophthalmitis.