Abstract
Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.
Keywords:
aging; genetics; neurovascular unit; primary open-angle glaucoma; treatment.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aged
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Animals
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Blood Pressure / physiology
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DNA Mutational Analysis
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Disease Models, Animal
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Eye / blood supply
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Female
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Glaucoma, Open-Angle / diagnosis
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Glaucoma, Open-Angle / genetics
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Glaucoma, Open-Angle / physiopathology
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Humans
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Intraocular Pressure / physiology
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Low Tension Glaucoma / diagnosis*
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Low Tension Glaucoma / genetics
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Low Tension Glaucoma / physiopathology
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Male
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Mice, Transgenic
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Prognosis
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Retinal Vessels / physiopathology
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Risk Factors
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Signal Transduction