Parenterally administered moderate sedation and paracervical block versus general anesthesia for hysteroscopic polypectomy: a pilot study comparing postoperative outcomes

J Minim Invasive Gynecol. 2015 Feb;22(2):193-8. doi: 10.1016/j.jmig.2014.09.008. Epub 2014 Nov 13.

Abstract

Study objective: To compare parenterally administered moderate sedation and paracervical block versus general anesthesia during day-case operative hysteroscopy for polypectomy in terms of patients' postoperative pain perception, operating time, and postoperative drug administration.

Design: A pilot study (Canadian Task Force classification I).

Setting: A university hospital.

Patients: Women undergoing hysteroscopic polypectomy procedures (N = 56).

Interventions: Hysteroscopic polypectomy with general anesthesia or moderate parenteral sedation and paracervical block.

Measurements and main results: The patients were divided into 2 groups: 26 underwent general anesthesia (group 1), and 30 were submitted to moderate parenteral sedation and a paracervical block (group 2). General anesthesia was induced with the laryngeal mask airway with propofol (1% 1-2.5 mg/kg) and fentanyl (1-2 μg/kg) and maintained with an infusion of propofol (2% 3-5 mg/kg/h). After the procedure, patients in the general anesthesia group received postoperative analgesic medication with paracetamol (20 mg/kg) and ketorolac (0.6 mg/kg) or tramadol (2-3 mg/kg). The group receiving moderate parenterally sedation and a paracervical block received a paracervical block with mepivacaine (1% 10 mL) and lidocaine (2% 10 mL) and received fentanyl (1 μg/kg) and propofol (1% 1-3 mg/kg/h) maintaining spontaneous breathing. A blind observer recorded the operative time and the discomfort of patients using a 4-step scale (0-3). The postoperative pain assessment was performed 3 hours after the procedure with a self-administered validated tool, the Brief Pain Inventory. We found that women receiving moderate parenteral sedation and a paracervical block perceived significantly less pain in daily activity (p < .001), walking (p < .001), daily work (p < .001), relations with others (p = .007), sleep (p < .001), and pain contrasting enjoyment of life (p < .001). The total amount of time spent in the operating room in group 2 was significantly lower than in group 1 (p < .014).

Conclusion: Moderate sedation plus a paracervical block for operative hysteroscopy is associated with reduced pain perception and a shorter operative time.

Keywords: General anesthesia; Operative hysteroscopy; Operative time; Pain; Paracervical block.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analgesics* / classification
  • Analgesics* / therapeutic use
  • Anesthesia, General* / adverse effects
  • Anesthesia, General* / methods
  • Anesthesia, Intravenous* / adverse effects
  • Anesthesia, Intravenous* / methods
  • Anesthesia, Obstetrical* / adverse effects
  • Anesthesia, Obstetrical* / methods
  • Anesthetics / classification
  • Anesthetics / therapeutic use
  • Canada
  • Conscious Sedation* / adverse effects
  • Conscious Sedation* / methods
  • Drug Administration Routes
  • Female
  • Humans
  • Hysteroscopy / methods
  • Middle Aged
  • Monitoring, Intraoperative / methods
  • Operative Time
  • Pain Measurement
  • Pain, Postoperative* / diagnosis
  • Pain, Postoperative* / prevention & control
  • Pilot Projects
  • Polyps / surgery*
  • Treatment Outcome
  • Uterine Diseases / surgery*

Substances

  • Analgesics
  • Anesthetics