Pharmacologic treatments for esophageal disorders

Ann N Y Acad Sci. 2014 Sep:1325:23-39. doi: 10.1111/nyas.12520.

Abstract

The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the role for ketamine and other alternative treatments in esophageal disorders; the use of linaclotide in the treatment of esophageal pain; the alginate test as a diagnostic criterion in gastroesophageal reflux disease (GERD); the use of baclofen in treatment of GERD; the effects of opioids on the esophagus; the use of antagonists on the receptor level in GERD; the effect of local formulation of drugs on the esophageal mucosa; and the use of electroencephalographic fingerprints to predict the effect of pharmacological treatment.

Keywords: EEG; OESO; alginate test; baclofen; esophagus; gastroesophageal reflux disease; ketamine; linaclotide; opiods; pharmacology.

Publication types

  • Congress

MeSH terms

  • Analgesics, Opioid / pharmacology
  • Analgesics, Opioid / therapeutic use
  • Animals
  • Baclofen / pharmacology
  • Baclofen / therapeutic use
  • Enteric Nervous System / drug effects
  • Enteric Nervous System / pathology
  • Esophageal Diseases / diagnosis*
  • Esophageal Diseases / drug therapy*
  • Gastroesophageal Reflux / diagnosis
  • Gastroesophageal Reflux / drug therapy
  • Humans
  • Pain / diagnosis*
  • Pain / drug therapy*
  • Peptides / pharmacology
  • Peptides / therapeutic use
  • Purinergic Antagonists / pharmacology
  • Purinergic Antagonists / therapeutic use
  • Treatment Outcome

Substances

  • Analgesics, Opioid
  • Peptides
  • Purinergic Antagonists
  • Baclofen
  • linaclotide