Brd4 is on the move during inflammation

Trends Cell Biol. 2014 Nov;24(11):615-6. doi: 10.1016/j.tcb.2014.09.005. Epub 2014 Oct 3.

Abstract

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

Keywords: BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Atherosclerosis / genetics*
  • Humans
  • Inflammation / genetics*
  • NF-kappa B p50 Subunit / immunology*
  • Nuclear Proteins / antagonists & inhibitors*
  • Transcription Factor RelA / immunology*
  • Transcription Factors / antagonists & inhibitors*

Substances

  • NF-kappa B p50 Subunit
  • Nuclear Proteins
  • Transcription Factor RelA
  • Transcription Factors