Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.
Keywords: BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer.
Copyright © 2014 Elsevier Ltd. All rights reserved.