Immunosuppressive activity of the retroviral envelope protein P 15E and its possible relationship to neoplasia

R Snyderman; G J Cianciolo

doi:10.1016/0167-5699(84)90097-5

Immunosuppressive activity of the retroviral envelope protein P 15E and its possible relationship to neoplasia

Immunol Today. 1984 Aug;5(8):240-4. doi: 10.1016/0167-5699(84)90097-5.

Authors

R Snyderman¹, G J Cianciolo

Affiliation

¹ Laboratory of Immune Effector Function, Howard Hughes Medical Institute Division of Rheumatology and Immunology, Department of Medicine Duke University Medical Center, Durham, NC, USA.

PMID: 25290146
DOI: 10.1016/0167-5699(84)90097-5

Abstract

Type C retroviral infections can cause profound immunosuppression as well as neoplasms. The retroviral envelope protein p15E has both immunosuppressive and anti-inflammatory activities which may contribute to the pathogenicity of retroviruses. Murine and human neoplastic cells, not infected with retroviruses, have recently been found to contain p15E like antigens. In this article Ralph Snyderman and George Cianciolo discuss the potential relationship between p15E production, immunosuppression and neoplasia.