Abstract
Ouabain- and bumetanide-resistant potassium fluxes were measured in human erythrocytes incubated in a medium containing calcium and a calcium ionophore. Pharmacological concentrations of rat atrial natriuretic peptide stimulated these fluxes. Although human erythrocytes lack atrial natriuretic peptide receptors, our results suggest that the hormone can modify transmembrane K+ movements.
MeSH terms
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Animals
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Atrial Natriuretic Factor / pharmacology*
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Bumetanide / pharmacology
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Calcimycin / pharmacology
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Calcium / pharmacology
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Egtazic Acid / pharmacology
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Erythrocytes / drug effects
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Erythrocytes / metabolism*
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Humans
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In Vitro Techniques
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Ouabain / pharmacology
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Potassium / blood*
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Quinine / pharmacology
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Rats
Substances
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Bumetanide
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Calcimycin
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Egtazic Acid
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Ouabain
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Atrial Natriuretic Factor
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Quinine
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Potassium
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Calcium