A 65-year-old female patient suffered biventricular failure due to severe lymphoid myocarditis. Mechanical circulatory support was established with peripheral arterial-venous extracorporeal membrane oxygenation (AV-ECMO). The left ventricle was relieved by subclavian Impella 5.0. AV-ECMO was weaned with the use of only Impella 5.0 until the 17th day of use, whereupon Impella was phased out. This case report illustrates the use-fulness of combined peripheral VA-ECMO with subclavian Impella 5.0 with the prospect of single use of the subclavian Impella 5.0 until cardiac recovery thereby avoiding central cannulation.