Safety assessment of 6-hydroxyindole as used in cosmetics

Int J Toxicol. 2014 Sep-Oct;33(3 Suppl):24S-35S. doi: 10.1177/1091581814533972.

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 6-hydroxyindole, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that 6-hydroxyindole is safe for use in oxidative hair dye formulations.

Keywords: 6-Hydroxyindole; cosmetics; safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carcinogenicity Tests
  • Consumer Product Safety*
  • Cosmetics / chemistry*
  • Dose-Response Relationship, Drug
  • Female
  • Hair Dyes / chemistry
  • Humans
  • Indoles / blood
  • Indoles / chemistry
  • Indoles / toxicity*
  • Male
  • Rats
  • Rats, Wistar
  • Toxicity Tests, Acute

Substances

  • Cosmetics
  • Hair Dyes
  • Indoles
  • 6-hydroxyindole