Abstract
The synthesis of a series of 4-phenylquinolines with substituents in 2,3 and 6-position of the quinoline nucleus is described. Serotoninergic activity towards 5HT1A, 5HT1B, 5HT2, 5HT1A + B receptors and the 5-HT-uptake site was also studied.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism
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Chemical Phenomena
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Chemistry
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Paroxetine
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Piperidines
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Quinolines / chemical synthesis*
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Quipazine / analogs & derivatives
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Quipazine / chemical synthesis*
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Quipazine / metabolism
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Rats
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Receptors, Serotonin / metabolism*
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Serotonin Antagonists
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Synapses / metabolism
Substances
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Piperidines
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Quinolines
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Receptors, Serotonin
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Serotonin Antagonists
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Paroxetine
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Quipazine