Mission CaMKIIγ: shuttle calmodulin from membrane to nucleus

Cell. 2014 Oct 9;159(2):235-7. doi: 10.1016/j.cell.2014.09.023.

Abstract

Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) channels to the nucleus.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism*
  • Cyclic AMP Response Element-Binding Protein / metabolism*

Substances

  • Cyclic AMP Response Element-Binding Protein
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2