This commentary is a response to a systematic review, recently published in Vaccine, which investigates the effectiveness of educational interventions in increasing uptake of the human papillomavirus vaccine. The systematic review by Fu et al. (2014) enhances the field's understanding of human papillomavirus vaccine interventions; however, their review contains a number of conceptual and methodological limitations. This commentary begins by addressing these limitations. We then address the importance of studying human papillomavirus vaccine interventions in diverse populations, and conclude by making recommendations for future research.