Amine-accelerated manganese-catalyzed aromatic C-H conjugate addition to α,β-unsaturated carbonyls

Chem Commun (Camb). 2014 Dec 4;50(93):14558-61. doi: 10.1039/c4cc07598f.

Abstract

Since 1987, the stoichiometric two-step C-H conjugate addition reactions have been developed. Herein we describe the first manganese-catalyzed one-step direct aromatic C-H conjugate addition to α,β-unsaturated carbonyls, which is accelerated by a catalytic amount of dicyclohexylamine. Experimental and computational studies substantiated the validity of the proposed catalytic cycle.