Canine susceptibility to human influenza viruses (A/pdm 09H1N1, A/H3N2 and B)

J Gen Virol. 2015 Feb;96(Pt 2):254-258. doi: 10.1099/vir.0.070821-0. Epub 2014 Oct 13.

Abstract

We investigated the infectivity and transmissibility of the human seasonal H3N2, pandemic (pdm) H1N1 (2009) and B influenza viruses in dogs. Dogs inoculated with human seasonal H3N2 and pdm H1N1 influenza viruses exhibited nasal shedding and were seroconverted against the viruses; this did not occur in the influenza B virus-inoculated dogs. Transmission of human H3N2 virus between dogs was demonstrated by observing nasal shedding and seroconversion in naïve dogs after contact with inoculated dogs. The seroprevalence study offered evidence of human H3N2 infection occurring in dogs since 2008. Furthermore, serological evidence of pdm H1N1 influenza virus infection alone and in combination with canine H3N2 virus was found in the serum samples collected from field dogs during 2010 and 2011. Our results suggest that dogs may be hosts for human seasonal H3N2 and pdm H1N1 influenza viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Disease Reservoirs
  • Dog Diseases / pathology
  • Dog Diseases / transmission*
  • Dog Diseases / virology*
  • Dogs
  • Humans
  • Influenza A Virus, H3N2 Subtype / growth & development
  • Influenza A Virus, H3N2 Subtype / isolation & purification*
  • Influenza B virus / growth & development
  • Influenza B virus / isolation & purification*
  • Influenza, Human / virology*
  • Orthomyxoviridae Infections / pathology
  • Orthomyxoviridae Infections / transmission
  • Orthomyxoviridae Infections / veterinary*
  • Orthomyxoviridae Infections / virology
  • Virus Shedding

Substances

  • Antibodies, Viral