A new TIPE of phosphoinositide regulator in cancer

Larissa S Moniz; Bart Vanhaesebroeck

doi:10.1016/j.ccell.2014.09.017

A new TIPE of phosphoinositide regulator in cancer

Cancer Cell. 2014 Oct 13;26(4):443-4. doi: 10.1016/j.ccell.2014.09.017.

Authors

Larissa S Moniz¹, Bart Vanhaesebroeck²

Affiliations

¹ UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. Electronic address: [email protected].
² UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. Electronic address: [email protected].

PMID: 25314070
DOI: 10.1016/j.ccell.2014.09.017

Abstract

Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may constitute a novel phosphoinositide metabolism regulator.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis
Humans
Neoplasms / metabolism*
Phosphatidylinositols / metabolism*
Phosphatidylinositols / physiology

Substances

Phosphatidylinositols

Abstract

Publication types

MeSH terms

Substances

Grants and funding