Cardiac autonomic nerve distribution and arrhythmia

Quan Liu; Dongmei Chen; Yonggang Wang; Xin Zhao; Yang Zheng

doi:10.3969/j.issn.1673-5374.2012.35.012

Cardiac autonomic nerve distribution and arrhythmia

Neural Regen Res. 2012 Dec 15;7(35):2834-41. doi: 10.3969/j.issn.1673-5374.2012.35.012.

Authors

Quan Liu¹, Dongmei Chen¹, Yonggang Wang¹, Xin Zhao¹, Yang Zheng¹

Affiliation

¹ Department of Cardiovascular Disease, the First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

PMID: 25317134
PMCID: PMC4190866
DOI: 10.3969/j.issn.1673-5374.2012.35.012

Abstract

Objective: To analyze the distribution characteristics of cardiac autonomic nerves and to explore the correlation between cardiac autonomic nerve distribution and arrhythmia.

Data retrieval: A computer-based retrieval was performed for papers examining the distribution of cardiac autonomic nerves, using heart, autonomic nerve, sympathetic nerve, vagus nerve, nerve distribution, rhythm and atrial fibrillation as the key words.

Selection criteria: A total of 165 studies examining the distribution of cardiac autonomic nerve were screened, and 46 of them were eventually included.

Main outcome measures: The distribution and characteristics of cardiac autonomic nerves were observed, and immunohistochemical staining was applied to determine the levels of tyrosine hydroxylase and acetylcholine transferase (main markers of cardiac autonomic nerve distribution). In addition, the correlation between cardiac autonomic nerve distribution and cardiac arrhythmia was investigated.

Results: Cardiac autonomic nerves were reported to exhibit a disordered distribution in different sites, mainly at the surface of the cardiac atrium and pulmonary vein, forming a ganglia plexus. The distribution of the pulmonary vein autonomic nerve was prominent at the proximal end rather than the distal end, at the upper left rather than the lower right, at the epicardial membrane rather than the endocardial membrane, at the left atrium rather than the right atrium, and at the posterior wall rather than the anterior wall. The main markers used for cardiac autonomic nerves were tyrosine hydroxylase and acetylcholine transferase. Protein gene product 9.5 was used to label the immunoreactive nerve distribution, and the distribution density of autonomic nerves was determined using a computer-aided morphometric analysis system.

Conclusion: The uneven distribution of the cardiac autonomic nerves is the leading cause of the occurrence of arrhythmia, and the cardiac autonomic nerves play an important role in the occurrence, maintenance, and symptoms of arrhythmia.

Keywords: acetylcholine; acetylcholine transferase; adrenergic receptor; arrhythmia; cardiac autonomic nerve; catecholamine; muscarinic M receptor; norepinephrine; parasympathetic nerve; sympathetic nerve; tyrosine hydroxylase; vagus nerve.