CpG-loaded multifunctional cationic nanohydrogel particles as self-adjuvanting glycopeptide antitumor vaccines

Adv Healthc Mater. 2015 Mar 11;4(4):522-7. doi: 10.1002/adhm.201400460. Epub 2014 Oct 18.

Abstract

Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.

Keywords: CpG codelivery; MUC1 glycopeptide; anti-tumor vaccines; cationic nanohydrogels; self-adjuvanting vaccines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Amino Acid Sequence
  • Animals
  • Cancer Vaccines / immunology*
  • Cations
  • Enzyme-Linked Immunosorbent Assay
  • Glycopeptides / chemistry
  • Glycopeptides / immunology*
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemical synthesis
  • Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Oligodeoxyribonucleotides / chemistry*

Substances

  • Adjuvants, Immunologic
  • CPG-oligonucleotide
  • Cancer Vaccines
  • Cations
  • Glycopeptides
  • Oligodeoxyribonucleotides
  • Hydrogel, Polyethylene Glycol Dimethacrylate