Recent results in the search for new molecules with ambergris odor

Chem Biodivers. 2014 Oct;11(10):1639-50. doi: 10.1002/cbdv.201400153.

Abstract

The synthesis of new odorant molecules is still a challenging task for the fragrance chemist, because now as ever it is difficult to predict the odor properties of small organic molecules. Therefore, certain tools, such as, e.g., lead-structure optimization of existing odorants, are helpful techniques. In this article, we describe the synthesis and the odor properties of a new molecule derived by the so-called 'seco' lead-structure optimization of the ambergris compound Ambroxide(®) . Based on these results, more representatives with similar structures have been synthesized and evaluated for their olfactory properties.

Keywords: Ambergris; Ambroxide; Structureodor relationship; ‘Seco-Ambroxide’.

MeSH terms

  • Ambergris / chemistry*
  • Heterocyclic Compounds, 3-Ring / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Odorants / analysis*
  • Perfume / chemistry*
  • Structure-Activity Relationship

Substances

  • Ambergris
  • Heterocyclic Compounds, 3-Ring
  • Perfume