Abstract
pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Sequence
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Cell-Penetrating Peptides / chemistry*
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Gold / chemistry*
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Hydrogen-Ion Concentration
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Immobilized Proteins / chemistry
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Metal Nanoparticles / chemistry*
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Models, Molecular
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Molecular Sequence Data
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Peptides / chemistry*
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Protein Structure, Secondary
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Surface Properties
Substances
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Cell-Penetrating Peptides
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Immobilized Proteins
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Peptides
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GALA peptide
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Gold