The study was designed to assess the association of ApolipoproteinB/ApolipoproteinA-I (ApoB/ApoA-I) ratio with metabolic syndrome, its components, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the population of Georgia. The subjects were 1522 Georgians of Caucasian origin aged 18-80 (653 women and 869 men) without diabetes mellitus. The subjects were divided into two groups. High ApoB/ApoA-I ratio group was defined as gender-specific upper quartile (≥0.88 for women and (≥1.0 for men) and low ApoB/ApoA-I ratio group as the remaining three quartiles (<0.88 for women and <1.0 for men). ApoB/ApoA-I ratio was significantly higher in patients with vs. without MetS (p<.0001). Mean values of ApoB/ApoA-I ratio significantly increased as the numbers of MetS components increased (p<.0001 in both sexes). After adjustment for age and gender, ApoB/ApoA-I ratio was associated significantly with MetS as definition (OR=1.86), IR as definition (OR=9.83), LDL-C (OR=1.99), systolic pressure (OR=3.31), diastolic pressure (OR=1.64), fasting glucose (OR=2.46), triglycerides (OR=2.52), high-density lipoprotein cholesterol (OR=7.08) (all p<0.05).