A mathematical model studying mosquito-stage transmission-blocking vaccines

Math Biosci Eng. 2014 Oct;11(5):1229-45. doi: 10.3934/mbe.2014.11.1229.

Abstract

A compartmental deterministic model is proposed to evaluate the effectiveness of transmission-blocking vaccines of malaria, which targets at the parasite stage in the mosquito. The model is rigorously analyzed and numerical simulations are performed. The results and implications are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computer Simulation
  • Culicidae / parasitology*
  • Humans
  • Malaria / immunology*
  • Malaria / parasitology
  • Malaria / prevention & control
  • Malaria / transmission
  • Malaria Vaccines / immunology*
  • Models, Immunological*
  • Plasmodium / immunology*

Substances

  • Malaria Vaccines