Systematic review of treatment effectiveness and outcome measures for enthesitis in psoriatic arthritis

J Rheumatol. 2014 Nov;41(11):2290-4. doi: 10.3899/jrheum.140878.

Abstract

Enthesitis is a characteristic feature of psoriatic arthritis (PsA) and is important in disease pathogenesis and classification. Use of clinical outcome measures for enthesitis is heterogeneous, and only 1 measure has been specifically developed and validated in PsA. Ultrasound and magnetic resonance imaging assessments of enthesitis may have advantages over clinical examination but are insufficiently studied. As part of an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), we performed a systematic literature review and identified randomized controlled trials with enthesitis outcomes in PsA. For each treatment agent we calculated treatment effect sizes (where applicable) and graded the level of evidence.

Keywords: ENTHESITIS; ENTHESOPATHY; OUTCOME MEASURES; PSORIATIC ARTHRITIS; TREATMENT.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antirheumatic Agents / administration & dosage*
  • Arthritis, Psoriatic / diagnosis
  • Arthritis, Psoriatic / drug therapy*
  • Biological Products / therapeutic use
  • Female
  • Humans
  • Joint Capsule / drug effects
  • Joint Capsule / physiopathology
  • Ligaments, Articular / drug effects
  • Ligaments, Articular / physiopathology
  • Male
  • Practice Guidelines as Topic*
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Rheumatic Diseases / diagnosis*
  • Rheumatic Diseases / drug therapy*
  • Risk Assessment
  • Severity of Illness Index
  • Societies, Medical / standards
  • Tendinopathy / drug therapy
  • Tendinopathy / physiopathology
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Biological Products