High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser

Sci Rep. 2014 Nov 4:4:6889. doi: 10.1038/srep06889.

Abstract

Lipid deposition inside the arterial wall is a key indicator of plaque vulnerability. An intravascular photoacoustic (IVPA) catheter is considered a promising device for quantifying the amount of lipid inside the arterial wall. Thus far, IVPA systems suffered from slow imaging speed (~50 s per frame) due to the lack of a suitable laser source for high-speed excitation of molecular overtone vibrations. Here, we report an improvement in IVPA imaging speed by two orders of magnitude, to 1.0 s per frame, enabled by a custom-built, 2-kHz master oscillator power amplifier (MOPA)-pumped, barium nitrite [Ba(NO3)2] Raman laser. This advancement narrows the gap in translating the IVPA technology to the clinical setting.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diagnostic Imaging / instrumentation*
  • Iliac Artery / pathology
  • Lasers
  • Lipids / analysis*
  • Phantoms, Imaging
  • Photoacoustic Techniques / instrumentation*
  • Plaque, Atherosclerotic / pathology*
  • Swine
  • Swine, Miniature

Substances

  • Lipids