Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina

Antimicrob Agents Chemother. 2015 Jan;59(1):717-20. doi: 10.1128/AAC.03838-14. Epub 2014 Nov 3.

Abstract

One hundred forty-three penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates obtained in Argentina from 2008 and 2012 were examined to detect blaTEM-135 genes and to investigate plasmid profiles and multiantigen sequence types. Forty-two PPNG isolates were found to carry TEM-135, and two contained a new TEM derivative characterized as TEM-220. The blaTEM-135 allele was carried by the Toronto/Rio and African plasmids. Molecular epidemiology revealed that two blaTEM-135 isolates were related to previously described isolates from Thailand and China, indicating a common evolutionary origin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Argentina / epidemiology
  • Genes, Bacterial / genetics
  • Gonorrhea / drug therapy
  • Gonorrhea / epidemiology
  • Gonorrhea / microbiology*
  • Humans
  • Molecular Sequence Data
  • Neisseria gonorrhoeae / drug effects
  • Neisseria gonorrhoeae / enzymology
  • Neisseria gonorrhoeae / genetics*
  • Phylogeny
  • Plasmids / genetics
  • Sequence Alignment
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics*

Substances

  • beta-Lactamases

Associated data

  • GENBANK/KM998962