Detection beyond Debye's length with an electrolyte-gated organic field-effect transistor

Adv Mater. 2015 Feb 4;27(5):911-6. doi: 10.1002/adma.201403541. Epub 2014 Nov 6.

Abstract

Electrolyte-gated organic field-effect transistors are successfully used as biosensors to detect binding events occurring at distances from the transistor electronic channel that are much larger than the Debye length in highly concentrated solutions. The sensing mechanism is mainly capacitive and is due to the formation of Donnan's equilibria within the protein layer, leading to an extra capacitance (CDON) in series to the gating system.

Keywords: Donnan equilibria; biosensors; electrostatic double layers; organic field-effect transistors; sensors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Avidin / chemistry
  • Biosensing Techniques / instrumentation*
  • Electrolytes / chemistry
  • Models, Molecular
  • Molecular Conformation
  • Organic Chemicals / chemistry*
  • Osmolar Concentration
  • Streptavidin / chemistry
  • Thiophenes / chemistry
  • Transistors, Electronic*

Substances

  • Electrolytes
  • Organic Chemicals
  • Thiophenes
  • poly(3-hexylthiophene)
  • Avidin
  • Streptavidin