Clinical isolates of Salmonella enterica serovar Agona producing NDM-1 metallo-β-lactamase: first report from Pakistan

Seema Irfan; Erum Khan; Kauser Jabeen; Pushpa Bhawan; Katie L Hopkins; Martin Day; Amna Nasir; Daniele Meunier; Neil Woodford

doi:10.1128/JCM.02396-14

Clinical isolates of Salmonella enterica serovar Agona producing NDM-1 metallo-β-lactamase: first report from Pakistan

J Clin Microbiol. 2015 Jan;53(1):346-8. doi: 10.1128/JCM.02396-14. Epub 2014 Nov 5.

Authors

Seema Irfan¹, Erum Khan², Kauser Jabeen², Pushpa Bhawan², Katie L Hopkins³, Martin Day³, Amna Nasir², Daniele Meunier³, Neil Woodford³

Affiliations

¹ Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan [email protected].
² Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan.
³ Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, Public Health England, London, England.

Abstract

We report two cases of infantile diarrhea due to multidrug-resistant, NDM-1 metallo-β-lactamase-producing Salmonella enterica serovar Agona from Pakistan. This study alerts toward possible risk of NDM-1 transmission to enteric fever pathogens and encourages microbiologists to consider active screening of carbapenem resistance in nontyphoidal Salmonella isolates.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Bacterial
Feces / microbiology
Humans
Infant
Microbial Sensitivity Tests
Pakistan
Salmonella Infections / drug therapy
Salmonella Infections / microbiology*
Salmonella enterica / drug effects
Salmonella enterica / enzymology*
Salmonella enterica / genetics
beta-Lactamases*

Substances

Anti-Bacterial Agents
beta-Lactamases
beta-lactamase NDM-1