In this study, the Authors take into consideration 70 male partners of women who showed (after medical and/or surgical therapy) cervical and/or vaginal relapsing and/or persistent lesions associated with HPV infections. Fifty-two (74%) of the male partners resulted "positive" for HPV genital infection by the colposcipc and/or cytologic examination. The histological examination of target biopsy performed on o macular lesion revealed slight-moderate dysplasia associated with HPV atypical alterations. persistent and/or recurrent cervical-vaginal HPV infection. For the therapy to be successful, we cannot overlook a diagnostic and therapeutic course that fits the couple.