Mitotane for 21-hydroxylase deficiency in an infertile man

N Engl J Med. 2014 Nov 20;371(21):2042-4. doi: 10.1056/NEJMc1410041.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Hyperplasia, Congenital / complications
  • Adrenal Hyperplasia, Congenital / drug therapy*
  • Adrenal Rest Tumor / complications
  • Adrenal Rest Tumor / drug therapy
  • Adult
  • Antineoplastic Agents, Hormonal / pharmacology
  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Azoospermia / drug therapy*
  • Azoospermia / etiology
  • Gonadotropins / deficiency
  • Hormones / blood
  • Humans
  • Male
  • Mitotane / pharmacology
  • Mitotane / therapeutic use*
  • Mutation
  • Steroid 21-Hydroxylase / genetics
  • Testicular Neoplasms / complications
  • Testicular Neoplasms / drug therapy
  • Testis / drug effects

Substances

  • Antineoplastic Agents, Hormonal
  • Gonadotropins
  • Hormones
  • Mitotane
  • CYP21A2 protein, human
  • Steroid 21-Hydroxylase

Supplementary concepts

  • Congenital adrenal hyperplasia due to 21 hydroxylase deficiency